Toribatake Y, Hutton W C, Tomita K, Boden S D
Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan.
Spine (Phila Pa 1976). 1998 May 15;23(10):1149-54. doi: 10.1097/00007632-199805150-00015.
A previously characterized rabbit model was used to study vascularization of the fusion mass in a posterolateral intertransverse process fusion.
To determine the interosseus origin of the new blood vessels in a posterolateral intertransverse process fusion mass and to test the hypothesis that bone incorporation and the extent of vascularization are closely related.
It has been reported that vascularization is essential for bone graft incorporation. There are, however, few reports dealing with vascularization of the spinal arthrodesis.
Thirty-one adult New Zealand White rabbits underwent bilateral intertransverse process fusion, using autogenous iliac crest bone graft. The rabbits were killed at 3 weeks (n = 6) and 6 weeks (n = 25) after surgery, and colored silicone was injected to fix the vasculature. A semiautomated image analysis system was used to assess the percentage of the area of vascularization in the fusion mass and the transverse processes.
The major interosseus blood supply for vascularization of the autogenous bone graft came from upper and lower transverse processes. There were three types of fusion mass observed at 6 weeks after surgery: solid type, solid type with cartilaginous cleft, and nonunion type. There was significantly less vascularization of the fusion mass and of the transverse processes in the nonunion type compared with that in the solid type and with that in the cartilaginous cleft type.
There is a close correlation between bone incorporation and the extent of vascularization in a posterolateral intertransverse process fusion.
采用先前已表征的兔模型来研究后外侧横突间融合术中融合块的血管化情况。
确定后外侧横突间融合块中新生血管的骨内起源，并验证骨融合与血管化程度密切相关这一假说。
据报道，血管化对于骨移植融合至关重要。然而，关于脊柱融合术血管化的报道较少。
31只成年新西兰白兔接受双侧横突间融合术，使用自体髂嵴骨移植。术后3周（n = 6）和6周（n = 25）处死兔子，并注入彩色硅橡胶以固定血管系统。使用半自动图像分析系统评估融合块和横突中血管化区域的百分比。
自体骨移植血管化的主要骨内血供来自上下横突。术后6周观察到三种类型的融合块：实心型、有软骨裂隙的实心型和不愈合型。与实心型和有软骨裂隙型相比，不愈合型融合块和横突的血管化明显较少。
后外侧横突间融合术中骨融合与血管化程度之间存在密切相关性。
