Weiss M
Section of Pharmacokinetics, Department of Pharmacology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Drug Metab Dispos. 1998 Jun;26(6):562-5.
Models describing the plasma concentration-time curves of generated metabolite after iv and oral drug administration are presented. Utilizing numerical inverse Laplace transformation, the method can readily be used for parameter estimation and model simulation in conjunction with appropriate curve-fitting software. The approach is not limited to compartment modeling and can be applied to any linear pharmacokinetic system exhibiting hepatic and renal elimination of the parent drug. The model is formulated for single and multiple dosing of the precursor, including bolus doses and/or infusions for iv administration and sustained-release dosage forms for oral administration.
本文展示了描述静脉注射和口服给药后生成代谢物的血浆浓度-时间曲线的模型。利用数值拉普拉斯逆变换，结合适当的曲线拟合软件，该方法可轻松用于参数估计和模型模拟。该方法不限于房室建模，可应用于任何表现出母体药物肝脏和肾脏消除的线性药代动力学系统。该模型适用于前体药物的单次和多次给药，包括静脉注射的推注剂量和/或输注以及口服给药的缓释剂型。
