Chonmaitree T, Heikkinen T
Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0371, USA.
Ann N Y Acad Sci. 1997 Dec 29;830:143-57. doi: 10.1111/j.1749-6632.1997.tb51886.x.
Taken together, there is ample evidence suggesting a role for viruses in the pathogenesis of OM. This evidence comes from numerous studies performed in animals and in vitro cell cultures, as well as in adults and children with URI and OM. Viruses induce host immune and inflammatory responses that result in pathology of the ET and the middle ear, and predispose the host in various ways to secondary bacterial infection. A suggested mechanism for the pathogenesis of OM following respiratory viral infection is presented in Figure 1.
综上所述，有充分证据表明病毒在中耳炎发病机制中起作用。这一证据来自于在动物和体外细胞培养中以及在患有上呼吸道感染和中耳炎的成人及儿童中进行的大量研究。病毒引发宿主免疫和炎症反应，导致咽鼓管和中耳出现病变，并以各种方式使宿主易患继发性细菌感染。图1展示了呼吸道病毒感染后中耳炎发病机制的一种推测机制。
