Boyle P
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan.
Arch Ital Urol Androl. 1998 Apr;70(2):77-82.
Acute urinary retention is an unpleasant, painful experience which requires immediate medical, and frequently surgical intervention. Population studies reveal that acute urinary retention is a common event: a 60 year-old man who survives a further 20 years has a 23 per cent probability of experiencing an acute episode of urinary retention. About half of acute retention episodes appear to be linked to general anaesthesia and a further large population due to the natural history of benign prostatic hyperplasia. The risk of acute urinary retention increases with increasing age. There are a number of other risk factors with risk increased in men with moderate and severe urinary symptoms, low peak urinary flow rates (less than 12 ml/sec) and among men with large prostates. Recent placebo-controlled randomised trials reveal that finasteride is associated with a 57 per cent reduction in the hazard ratio of acute urinary retention when used for at least two years. Since finasteride acts in a positive manner on the major risk factors (finasteride use increases peak urinary flow rate, reduces symptom scores in moderately symptomatic men and reduces prostate volume), this result is not too surprising. It remains to be determined what the risk factors for anaesthesia-induced acute retention are and how they can be altered. Nevertheless, the improvement of our knowledge of the epidemiology of acute urinary retention in the past 12 months is impressive.
急性尿潴留是一种令人不适且疼痛的经历,需要立即进行医疗干预,且常常需要手术治疗。人群研究表明,急性尿潴留是一种常见情况:一名60岁且还能再活20年的男性发生急性尿潴留的概率为23%。大约一半的急性尿潴留发作似乎与全身麻醉有关,另有一大部分与良性前列腺增生的自然病程有关。急性尿潴留的风险随年龄增长而增加。还有一些其他风险因素,在有中度和重度泌尿系统症状、低尿流率峰值(低于12毫升/秒)的男性以及前列腺体积较大的男性中,风险会增加。最近的安慰剂对照随机试验表明,非那雄胺至少使用两年时,与急性尿潴留风险比降低57%有关。由于非那雄胺对主要风险因素有积极作用(使用非那雄胺可提高尿流率峰值、降低中度症状男性的症状评分并减小前列腺体积),所以这个结果并不太令人惊讶。麻醉诱导的急性尿潴留的风险因素是什么以及如何改变这些因素仍有待确定。然而,在过去12个月里,我们对急性尿潴留流行病学的认识有了显著提高。