Boneschi M, Erba M, Beretta L, Miani S, Bortolani E M
Istituto di Chirurgia Generale e Cardiovascolare, Università degli studi, Milano.
Minerva Chir. 1998 Mar;53(3):167-72.
We performed on 9 patients with adrenal cortical carcinoma a retrospective study during 1967-1995 to evaluate the most important prognostic factors. Four patients were males and five females (mean age: 40.3 years). Five patients had endocrine symptoms (55%) and four had "non-functioning" tumors (45%). The tumor involved the left adrenal gland in 5 cases and the right in 4. The mean diameter of the neoplasm was 9.5 cm, with a mean weight of 411 g. The average duration of symptoms before diagnosis was 7.3 months. One patient had invasion of the inferior vena cava with liver metastases. Eight patients underwent curative surgery, the median survival time was 13.7 months, only 1 patient is alive after 18 months from surgical resection. We concluded that adrenal carcinomas have poor prognosis; staging and grading of the neoplasm, and age of the patient at diagnosis are predictors of survival.
我们对9例肾上腺皮质癌患者在1967年至1995年期间进行了一项回顾性研究，以评估最重要的预后因素。4例为男性，5例为女性（平均年龄：40.3岁）。5例患者有内分泌症状（55%），4例有“无功能”肿瘤（45%）。肿瘤累及左肾上腺5例，右肾上腺4例。肿瘤平均直径为9.5 cm，平均重量为411 g。诊断前症状的平均持续时间为7.3个月。1例患者有下腔静脉侵犯伴肝转移。8例患者接受了根治性手术，中位生存时间为13.7个月，自手术切除后仅1例患者在18个月后仍存活。我们得出结论，肾上腺癌预后较差；肿瘤的分期和分级以及诊断时患者的年龄是生存的预测因素。
