Duronio V, Scheid M P, Ettinger S
Department of Medicine, University of British Columbia, Jack Bell Research Centre, Vancouver, BC, Canada.
Cell Signal. 1998 Apr;10(4):233-9. doi: 10.1016/s0898-6568(97)00129-0.
The phosphatidylinositol (PI) 3-kinase family of enzymes is now known to be regulated by several different upstream pathways in response to virtually all growth factors and cytokines. In the past few years, the phosphoinositides phosphorylated at the 3-OH position of the inositol ring have been shown to be lipid second messengers that may directly or indirectly regulate the activity of several different serine/threonine kinases. Consistent with the many different cellular events in which PI 3-kinase plays an important role, a diverse group of serine/threonine kinases are regulated downstream of PI 3-kinases, including protein kinase C (PKC) isoforms, p70 S6 kinase, and PKB/Akt. This review summarises studies done primarily in the past few years that have begun to unravel these targets of PI 3-kinase activity.
现在已知磷脂酰肌醇（PI）3激酶家族的酶受几种不同的上游途径调控，以响应几乎所有的生长因子和细胞因子。在过去几年中，已证明在肌醇环3-OH位置磷酸化的磷酸肌醇是脂质第二信使，它们可能直接或间接调节几种不同丝氨酸/苏氨酸激酶的活性。与PI 3激酶在其中发挥重要作用的许多不同细胞事件一致，一组不同的丝氨酸/苏氨酸激酶在PI 3激酶下游受到调控，包括蛋白激酶C（PKC）亚型、p70 S6激酶和PKB/Akt。本综述总结了主要在过去几年中开展的研究，这些研究已开始揭示PI 3激酶活性的这些靶点。
