Leblanc H, Yen S S
Am J Obstet Gynecol. 1976 Sep 15;126(2):162-4. doi: 10.1016/0002-9378(76)90269-6.
The time course of simultaneous changes in prolactin (PRL) and growth hormone secretion in response to a single dose of L-dopa and chlorpromazine was determined in normal women. L-Dopa induced greater, but shorter (30 minutes), growth hormone release than concomitant suppression of PRL secretion. The PRL peak following chlorpromazine occurred at the same time as the nadir of PRL after L-dopa (3.5 hours). The quantity of PRL release inhibited by L-dopa equaled the amount of PRL secretion during the period of rebound, suggesting L-dopa inhibits PRL release, but not synthesis, by the pituitary.
在正常女性中测定了单次给予左旋多巴和氯丙嗪后催乳素（PRL）和生长激素分泌同时变化的时间过程。左旋多巴诱导的生长激素释放量更大，但持续时间较短（30分钟），同时会抑制PRL分泌。氯丙嗪给药后PRL峰值与左旋多巴给药后PRL谷值出现的时间相同（3.5小时）。左旋多巴抑制的PRL释放量与反弹期的PRL分泌量相等，提示左旋多巴抑制垂体PRL的释放，但不抑制其合成。
