肾母细胞瘤化疗后肾切除术后手术并发症的罕见性。国际小儿肿瘤学会-试验与研究“SIOP-9”的经验。国际小儿肿瘤学会肾母细胞瘤试验与研究委员会

Rarity of surgical complications after postchemotherapy nephrectomy for nephroblastoma. Experience of the International Society of Paediatric Oncology-Trial and Study "SIOP-9". International Society of Paediatric Oncology Nephroblastoma Trial and Study Committee.

作者信息

Godzinski J, Tournade M F, deKraker J, Lemerle J, Voute P A, Weirich A, Ludwig R, Rapala M, Skotnicka G, Gauthier F, Moorman-Voestermans C G, Buerger D, VanVeen A, Sawicz-Birkowska K

机构信息

Department of Paediatric Surgery, Marciniak Hospital, Wrocław, Poland.

出版信息

Eur J Pediatr Surg. 1998 Apr;8(2):83-6. doi: 10.1055/s-2008-1071127.

DOI:10.1055/s-2008-1071127

PMID:9617606

Abstract

The aim of the study was to assess rates and types of nephrectomy-related complications in children nephrectomized for nephroblastoma after preoperative chemotherapy. Records of 598 Wilms' tumour patients registered in the International Society of Paediatric Oncology Trial & Study No. 9 (SIOP-9), and pretreated correctly according to the protocol with vincristine + actinomycin D +/- epirubicine or adriamycin prior to nephrectomy, were retrospectively reviewed. Forty-nine patients (8%), who suffered from 54 complications, were identified. Most frequent events were small-bowel occlusions (3.7%) and tumour ruptures (2.8%). Other complications were registered in 2.0% of cases. The low rate of nephrectomy complications and no deaths related to registered ones, are another argument for preoperative chemotherapy in Wilms' tumour patients.

摘要

本研究的目的是评估术前化疗后因肾母细胞瘤接受肾切除术的儿童患者中与肾切除术相关并发症的发生率和类型。对国际小儿肿瘤学会第9号试验与研究（SIOP-9）中登记的598例威尔姆斯瘤患者的记录进行了回顾性分析，这些患者在肾切除术之前均按照方案正确地接受了长春新碱+放线菌素D+/-表柔比星或阿霉素的预处理。共识别出49例（8%）发生54种并发症的患者。最常见的事件是小肠梗阻（3.7%）和肿瘤破裂（2.8%）。其他并发症的发生率为2.0%。肾切除术并发症发生率低且无与所记录并发症相关的死亡病例，这是支持威尔姆斯瘤患者术前化疗的另一个论据。