细胞肌动蛋白与人类呼吸道合胞病毒（HRSV）之间的相互作用。

Interactions between cellular actin and human respiratory syncytial virus (HRSV).

作者信息

Ulloa L, Serra R, Asenjo A, Villanueva N

机构信息

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Universidad Autonóma de Madrid, Cantoblanco, Spain.

出版信息

Virus Res. 1998 Jan;53(1):13-25. doi: 10.1016/s0168-1702(97)00121-4.

DOI:10.1016/s0168-1702(97)00121-4

PMID:9617766

Abstract

Actin the main component of the cellular microfilament network, is present in human respiratory syncytial virus (HRSV) purified virions, as an internal component. This fact and the results of immunoprecipitation studies indicate that during HRSV infection in HEp-2 cells there are interactions between cellular actin and viral components, that can promote a transitory increase in the polymerization of synthetized actin, mainly of the beta isotype. This increased actin polymerization can be related with the formation of cytoplasmic extensions, that contain beta actin and viral particles observed in the HRSV infected HEp-2 cells. The formation of these structures may indicate that HRSV has developed an actin-based motility system similar to that described for other viral and bacterial systems.

摘要

肌动蛋白是细胞微丝网络的主要成分，作为内部成分存在于人类呼吸道合胞病毒（HRSV）纯化病毒粒子中。这一事实以及免疫沉淀研究结果表明，在HEp-2细胞感染HRSV期间，细胞肌动蛋白与病毒成分之间存在相互作用，这可促进合成肌动蛋白（主要是β同种型）聚合的短暂增加。这种肌动蛋白聚合增加可能与细胞质延伸的形成有关，在感染HRSV的HEp-2细胞中观察到这些细胞质延伸含有β肌动蛋白和病毒颗粒。这些结构的形成可能表明HRSV已经发展出一种基于肌动蛋白的运动系统，类似于其他病毒和细菌系统中所描述的那样。