Okano H, Masuoka H, Kamei S, Seko T, Koyabu S, Tsuneoka K, Tamai T, Ueda K, Nakazawa S, Sugawa M, Suzuki H, Watanabe M, Yatani R, Nakano T
Division of Internal Medicine, Owase General Hospital, Mie.
Intern Med. 1998 Mar;37(3):330-3. doi: 10.2169/internalmedicine.37.330.
A 55-year-old man had rhabdomyolysis and myocardial damage induced by palytoxin. Weakness and myalgia of four extremities occurred five hours after eating a fish. Rhabdomyolysis developed and the serum creatine phosphokinase (CK) was elevated to 40,000 IU/l on the 3rd day. Gastric lavage with activated charcoal and forced mannitol-alkaline diuresis therapy were performed. The patient recovered with no complication such as renal failure. In this case, palytoxin was suggested to induce myocardial damage which was demonstrated by an elevation of the myosin light chain level and a change in electrocardiogram.
一名55岁男性因岩沙海葵毒素导致横纹肌溶解和心肌损伤。食用一条鱼五小时后出现四肢无力和肌痛。横纹肌溶解症逐渐发展，第3天时血清肌酸磷酸激酶（CK）升高至40,000 IU/l。进行了活性炭洗胃和强制甘露醇-碱性利尿治疗。患者康复，未出现肾衰竭等并发症。在该病例中，岩沙海葵毒素被认为可导致心肌损伤，这通过肌球蛋白轻链水平升高和心电图变化得以证实。
