Sommer A, Toureau S, Cornet P, Midy C, Pettiss S T
Am J Ophthalmol. 1976 Sep;82(3):439-46. doi: 10.1016/0002-9394(76)90492-x.
The prevalence of presumed vitamin A-related corneal scars among 5,589 preschool-age Haitian children ranged from 1.2 per 1,000 in the south, to almost 1% in the famine-afflicted north. These scars accounted for at least 45% of all corneal scars, and all bilateral corneal blindness encountered. Most lesions were acquired during the first three years of life. There was no variation by sex or ecology of the sample site. This country of 5.5 million inhabitants acquires 345 new surviving cases of vitamin A-related corneal destruction, over one fourth bilaterally blind, each year, although local ophthalmologists rarely encounter the disease and Bitot's spots were absent from our study population. Countrywide clinical prevalence surveys are the only unbiased means of determining the magnitude, severity, and geographic distribution of vitamin A-related corneal destruction, prerequisites for the design of public health prevention programs.
在5589名海地学龄前儿童中，疑似维生素A缺乏相关角膜瘢痕的患病率在南部地区为每1000人中有1.2例，在受灾荒影响的北部地区接近1%。这些瘢痕至少占所有角膜瘢痕的45%，以及所有双侧角膜盲病例。大多数病变发生在生命的头三年。样本地点的性别或生态环境并无差异。这个拥有550万人口的国家，每年有345例新存活的维生素A缺乏相关角膜破坏病例，其中超过四分之一为双侧失明，尽管当地眼科医生很少遇到这种疾病，且我们的研究人群中没有毕脱斑。全国范围内的临床患病率调查是确定维生素A缺乏相关角膜破坏的规模、严重程度和地理分布的唯一无偏倚方法，这些都是设计公共卫生预防项目的先决条件。
