Klapdor K, Van Der Staay F J
CNS Research, Bayer, Cologne, Germany.
Physiol Behav. 1998 Mar;63(5):903-9. doi: 10.1016/s0031-9384(98)00003-1.
The working memory version of the Morris water escape task, the repeated acquisition task, consists of trial pairs in which an animal is started twice from the same start position. Animals have mastered this task when they need less time to find the platform in the second of the two trials. In this study, study, male C57BL mice were trained on this task with massed, spaced, or spaced delay trials in which there was a 90-min delay between the first and second trials of a pair. The mice trained with spaced trials learned the repeated acquisition task, whereas the mice trained with massed or spaced delay trials were not consistently able to do so. When the mice had reached a stable baseline performance, the middle cerebral artery (MCA) was occluded or the mice were sham-operated. Then, the effects of the MCA occlusion (MCA-O) on the performance in the repeated acquisition tasks were studied. MCA occlusion hardly affected the performance in this task, irrespective of the spacing condition of the trials, although surgery per se seemed to have a transient disruptive effect.
莫里斯水迷宫任务的工作记忆版本，即重复获取任务，由试验对组成，在这些试验对中，动物从相同的起始位置开始两次。当动物在两次试验中的第二次试验中找到平台所需时间减少时，它们就掌握了这项任务。在本研究中，雄性C57BL小鼠接受了集中、间隔或间隔延迟试验的训练，在间隔延迟试验中，一对试验的第一次和第二次试验之间有90分钟的延迟。接受间隔试验训练的小鼠学会了重复获取任务，而接受集中或间隔延迟试验训练的小鼠则不能始终如一地做到这一点。当小鼠达到稳定的基线表现时，大脑中动脉（MCA）被闭塞或小鼠接受假手术。然后，研究了大脑中动脉闭塞（MCA-O）对重复获取任务表现的影响。尽管手术本身似乎有短暂的干扰作用，但无论试验的间隔条件如何，MCA闭塞对这项任务的表现几乎没有影响。
