我们应该以组织肾素-血管紧张素系统为目标吗？

Should we aim at tissue renin-angiotensin systems?

作者信息

Smits J F, Passier R C, Daemen M J

机构信息

Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM), Universiteit Maastricht, The Netherlands.

出版信息

Pharm World Sci. 1998 Jun;20(3):93-9. doi: 10.1023/a:1008621913932.

DOI:10.1023/a:1008621913932

PMID:9618731

Abstract

Recent developments in our knowledge of the renin-angiotensin system (RAS) necessitate an update of the classical view on this system. These developments pertain to the pathways leading to formation of angiotensin II and other active metabolites, their receptors, biological functions and the presence of renin-angiotensin systems in tissues. The implications of the above new developments for the current interest in tissue renin-angiotensin systems as potential targets for drug therapy in cardiovascular disease are discussed in this review.

摘要

我们对肾素-血管紧张素系统（RAS）的认识最近有了新进展，这使得对该系统的经典观点需要更新。这些进展涉及导致血管紧张素II和其他活性代谢产物形成的途径、它们的受体、生物学功能以及组织中肾素-血管紧张素系统的存在。本综述讨论了上述新进展对当前将组织肾素-血管紧张素系统作为心血管疾病药物治疗潜在靶点的研究兴趣的影响。