Huber T L, Zon L I
Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Semin Immunol. 1998 Apr;10(2):103-9. doi: 10.1006/smim.1998.0111.
Hematopoiesis is the generation, proliferation and differentiation of hematopoietic stem cells (HSCs) into the erythroid, myeloid and lymphoid lineages. The HSC is a ventral mesodermal derivative that arises due to inductive and patterning processes triggered by bone morphogenetic protein 4 (BMP-4). Recent studies in Xenopus laevis have identified families of transcription factors that participate in hematopoietic development. Transcription factor families, such as the SMADs, Mixs and Vents pattern mesoderm to a ventral fate which ultimately results in the expression of hematopoietic-specific transcription factors such as GATA-1 and SCL. This transcriptional regulatory network enforces the correct temporal and spatial expression of the blood program.
造血作用是造血干细胞（HSCs）生成、增殖并分化为红细胞系、髓细胞系和淋巴细胞系的过程。造血干细胞是腹侧中胚层的衍生物，由骨形态发生蛋白4（BMP - 4）触发的诱导和模式形成过程产生。近期对非洲爪蟾的研究已经确定了参与造血发育的转录因子家族。转录因子家族，如SMADs、Mixs和Vents，将中胚层模式化为腹侧命运，最终导致造血特异性转录因子如GATA - 1和SCL的表达。这个转录调控网络确保了血液程序在正确的时间和空间上的表达。
