Nichogiannopoulou A, Trevisan M, Friedrich C, Georgopoulos K
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA.
Semin Immunol. 1998 Apr;10(2):119-25. doi: 10.1006/smim.1998.0113.
Studies on the molecular mechanisms that control hemopoietic differentiation have focused on signaling cascades and nuclear effectors that drive this complex developmental system in a regulated fashion. Here we review the role of Ikaros, the founding member of a unique family of zinc finger transcription factors in this developmental process. Studies on an Ikaros null mutation have revealed an essential role for this factor in lymphoid cell fate determination and at subsequent branch points of the T cell differentiation pathway. Differences in the phenotypes of a null and a dominant negative (DN) Ikaros mutation provide insight into a regulatory network through which Ikaros proteins exert their effects in development. In addition a comparative analysis of the hemopoietic stem cell and precursor compartment resulting from the two Ikaros mutations reveals a profound yet not absolute requirement for Ikaros in the production and differentiation of these populations.
对控制造血分化分子机制的研究聚焦于信号级联反应和核效应因子，这些因子以一种受调控的方式驱动这个复杂的发育系统。在此，我们综述Ikaros在这一发育过程中的作用，Ikaros是锌指转录因子独特家族的创始成员。对Ikaros无效突变的研究揭示了该因子在淋巴细胞命运决定以及T细胞分化途径后续分支点中的关键作用。无效突变和显性负性（DN）Ikaros突变表型的差异为Ikaros蛋白在发育过程中发挥作用的调控网络提供了深入了解。此外，对由两种Ikaros突变产生的造血干细胞和前体细胞区室的比较分析揭示了Ikaros在这些细胞群体的产生和分化中有着深刻但并非绝对的需求。
