McNamara P D, Rea C, Ozegović B, Segal S
Am J Physiol. 1976 Jul;231(1):9-13. doi: 10.1152/ajplegacy.1976.231.1.9.
The uptake of D-[(14)C]mannose by adult rat kidney cortex slices has been examined. The process involved appeared to be saturable and oxygen dependent and to be inhibited by glucose, galactose, chi-methyl-D-glucoside, and phlorizin. Extensive metabolism of the sugar occurred. (14)CO(2) was produced to an extent comparable to that from D-glucose. Radioactive compounds accumulated in the tissue, approximately 50% of which were in the form of phosphorylated or other polar intermediates. The remaining neutral fraction consisted of mannose with a small amount of label in glucose and an unidentified compound which behaves like an alditol. Mannose concentration in the intracellular fluid was never greater than that of the medium.
已对成年大鼠肾皮质切片对D-[(14)C]甘露糖的摄取进行了研究。所涉及的过程似乎具有饱和性且依赖氧气，并受到葡萄糖、半乳糖、甲基-D-葡萄糖苷和根皮苷的抑制。该糖发生了广泛的代谢。产生的(14)CO(2)量与D-葡萄糖产生的量相当。放射性化合物在组织中积累，其中约50%为磷酸化或其他极性中间体的形式。其余的中性部分由甘露糖组成，葡萄糖中有少量标记，还有一种表现得像糖醇的未知化合物。细胞内液中的甘露糖浓度从未高于培养基中的浓度。
