A study of central and peripheral nerve conduction in patients with primary hypothyroidism: the effects of thyroxine replacement.

Somato-Sensory Evoked Potential (SSEP) and Peripheral Nerve Conduction (PNC) studies were performed in twenty patients with primary hypothyroidism to elucidate the changes of central and peripheral nervous systems in hypothyroid state and the effects of thyroxine replacement. Before thyroxine replacement therapy, eleven patients had significantly delayed SSEP (prolonged latencies of N9, N13, or N20), and only three patients had prolonged central conduction time (between N13 and N20). PNC abnormalities with decreased conduction velocity and diminished amplitudes were found in fourteen patients. After thyroxine treatment, both SSEP and PNC studies demonstrated significant improvement and paralleled the clinical neurological amelioration. The central and peripheral conduction velocities returned to normal limits, while the abnormality in amplitude still persisted. There were also discrepancies between SSEP and PNC studies in both the abnormality pattern and the recovery potential. Our observations may suggest: firstly, both the SSEP and PNC studies may be useful, alternative tools in monitoring the neurological disorders in hypothyroidism; and secondly, the pathogenesis of central and peripheral nervous dysfunction in hypothyroidism may be via different mechanisms.