John S, Workman J L
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802-4500, USA.
Bioessays. 1998 Apr;20(4):275-9. doi: 10.1002/(SICI)1521-1878(199804)20:4<275::AID-BIES1>3.0.CO;2-P.
A hallmark feature of mitosis is the extinction of bulk cellular transcription. The mechanism by which transcription is abrogated is likely linked to mitotic specific events such as chromosome condensation. Recent studies that probe the structure of genes that can be reactivated rapidly after mitotic repression (early G1) suggest that there are structural distortions in the promoter regions of these genes. These distortions are absent in genes that are typically repressed or reactivated in later phases of the cell cycle (late G1, S, or G2). Such changes in the chromatin structure of these genes may create a transient window for transcription factor binding and rapid reactivation of genes in subsequent phases of the cell cycle.
有丝分裂的一个标志性特征是大量细胞转录的终止。转录被废除的机制可能与有丝分裂特异性事件如染色体凝聚有关。最近对在有丝分裂抑制（G1期早期）后能迅速重新激活的基因结构进行探测的研究表明，这些基因的启动子区域存在结构畸变。在细胞周期后期（G1期晚期、S期或G2期）通常被抑制或重新激活的基因中不存在这种畸变。这些基因染色质结构的此类变化可能为转录因子结合以及在细胞周期后续阶段基因的快速重新激活创造一个短暂的窗口。
