Williams R W
California Institute of Technology, Division of Biology, Pasadena 91125, USA.
Bioessays. 1998 Apr;20(4):280-2. doi: 10.1002/(SICI)1521-1878(199804)20:4<280::AID-BIES2>3.0.CO;2-U.
Homeodomain-containing transcription factors play a variety of important roles in plant, animal, and fungal development. Mutational and evolutionary analysis is beginning to pinpoint specific roles of homeobox genes in plant meristem function. Even though many different plant homeobox genes encode very similar homeodomain sequences, overexpression studies suggest the existence of several levels of regulation that may specify the functions of the different proteins. Recent analysis of the maize Knotted1 gene and its orthologue in barley demonstrates some of these regulatory processes.
含同源异型结构域的转录因子在植物、动物和真菌的发育过程中发挥着多种重要作用。突变和进化分析开始明确同源异型框基因在植物分生组织功能中的具体作用。尽管许多不同的植物同源异型框基因编码非常相似的同源异型结构域序列，但过表达研究表明存在多个调控水平，这些调控水平可能决定了不同蛋白质的功能。最近对玉米Knotted1基因及其在大麦中的直系同源基因的分析揭示了其中一些调控过程。
