Chang B, Lee Y, Ku Y, Bae K, Chung C
Planta Med. 1998 May;64(4):367-9. doi: 10.1055/s-2006-957453.
Magnolol (1) and honokiol (2), main compounds from the stem bark of Magnolia obovata Thunb., were evaluated for an antimicrobial activity against periodontopathic microorganisms, Porphyromonas gingivalis, Prevotella gingivalis, Actinobacillus actinomycetemcomitans, Capnocytophaga gingivalis, and Veillonella disper, and a cytotoxicity against human gingival fibroblasts and epithelial cells. Our results indicate that magnolol and honokiol, although less potent than chlorhexidine, show a significant antimicrobial activity against these microorganisms, and a relatively low cytotoxic effect on human gingival cells. Thus, it is suggested that magnolol and honokiol may have a potential therapeutic use as a safe oral antiseptic for the prevention and the treatment of periodontal disease.
厚朴酚（1）与和厚朴酚（2）是凹叶厚朴茎皮中的主要化合物，对牙周病原菌牙龈卟啉单胞菌、牙龈普氏菌、伴放线放线杆菌、牙龈二氧化碳嗜纤维菌和殊异韦荣球菌的抗菌活性以及对人牙龈成纤维细胞和上皮细胞的细胞毒性进行了评估。我们的结果表明，厚朴酚与和厚朴酚虽然效力低于氯己定，但对这些微生物具有显著的抗菌活性，且对人牙龈细胞的细胞毒性相对较低。因此，提示厚朴酚与和厚朴酚作为预防和治疗牙周疾病的安全口腔抗菌剂可能具有潜在的治疗用途。
