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吩噻嗪诱导的锥体外系综合征的抗胆碱能加重

Anticholinergic exacerbation of phenothiazine-induced extrapyramidal syndrome.

作者信息

Alpert M, Diamond F, Laski E M

出版信息

Am J Psychiatry. 1976 Sep;133(9):1073-5. doi: 10.1176/ajp.133.9.1073.

DOI:10.1176/ajp.133.9.1073
PMID:961932
Abstract

The authors used tremography to record the bilateral digital tremor of a patient showing extrapyramidal system effects in response to withdrawal from phenothiazines. They found that changes in the amplitude of tremor correlated with clinical ratings of extrapyramidal disturbance. Changes in the amplitude and in the spectrum of tremor were similar to the bipolar paradoxical changes seen during intoxication with an anticholinergic psychotogen.

摘要

作者使用震颤描记法记录了一名因停用吩噻嗪类药物而出现锥体外系效应患者的双侧手指震颤。他们发现,震颤幅度的变化与锥体外系障碍的临床评分相关。震颤幅度和频谱的变化类似于抗胆碱能致幻剂中毒时出现的双相矛盾变化。

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