Reddy A T, Packer R J
Children's Hospital of Alabama, Division of Pediatric Neurology, University of Alabama, Birmingham 35233, USA.
Curr Opin Oncol. 1998 May;10(3):186-93. doi: 10.1097/00001622-199805000-00003.
Much of the recent change in the management of brain tumors in children has centered on the expanded use of chemotherapy. The addition of chemotherapy has resulted in better survival rates for children with medulloblastoma and altered the management for those with low-grade gliomas. For other tumor types, therapeutic advances have been slower. High-dose chemotherapy increasingly is being employed to treat malignant childhood tumors, with variable results.
儿童脑肿瘤治疗管理方面最近的许多变化都集中在化疗使用的扩大上。化疗的加入提高了髓母细胞瘤患儿的生存率，并改变了低级别胶质瘤患儿的治疗方式。对于其他肿瘤类型，治疗进展则较为缓慢。高剂量化疗越来越多地被用于治疗儿童恶性肿瘤，但效果不一。
