Bauduer F, Ducout L, Dastugue N, Capdupuy C, Renoux M
Service des Maladies du Sang et Chimiothérapie, CH Côte Basque, Bayonne, France.
Leuk Res. 1998 Mar;22(3):205-8. doi: 10.1016/s0145-2126(97)00159-8.
Epidemiologic studies concerning myelodysplastic syndromes (MDS) are rare. The estimated incidence varies between 1 and 12.6/100,000/year. The aim of this work was to compare our own experience with these data. Our general hospital represents a structure with 1197 beds which serves a population of 290,000 individuals (French Basques). Most of the inhabitants live in a rural environnement. Twenty percent of the population are aged over 65. During a 4-year period (1993-1996), 90 new cases of MDS were diagnosed on bone marrow studies in our laboratory. Among FAB subtypes refractory anemia (RA) represented 27 cases (31%), RA with ring sideroblasts (RARS): 21 (23%), RA with excess of blasts (RAEB) and in transformation (RAEB-t): 22 (24%), chronic myelomonocytic leukemia (CMML): 10 (11%). Ten cases were unclassifiable (11%). Therapy-related MDS were seen in 8 patients. The sex ratio was 1 and the mean age of the patients was 74.3 (range: 23-96), 37% of them being 80 years or older. The calculated incidence was 7.7/100,000/year for the entire cohort and 31.4/100,000/year for people over 65.
关于骨髓增生异常综合征（MDS）的流行病学研究很少见。估计发病率在每年1至12.6/10万之间。这项工作的目的是将我们自己的经验与这些数据进行比较。我们的综合医院有1197张床位，服务于29万人口（法国巴斯克人）。大多数居民生活在农村环境中。20%的人口年龄在65岁以上。在4年期间（1993 - 1996年），我们实验室通过骨髓研究诊断出90例新的MDS病例。在FAB亚型中，难治性贫血（RA）有27例（31%），环形铁粒幼细胞性难治性贫血（RARS）：21例（23%），伴原始细胞增多的难治性贫血（RAEB）及转化型（RAEB - t）：22例（24%），慢性粒 - 单核细胞白血病（CMML）：10例（11%）。10例无法分类（11%）。8例患者出现治疗相关的MDS。男女比例为1，患者的平均年龄为74.3岁（范围：23 - 96岁），其中37%的患者年龄在80岁及以上。整个队列的计算发病率为每年7.7/10万，65岁以上人群为每年31.4/10万。
