IL-15在体内对记忆表型CD8 + T细胞的强效和选择性刺激。

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

作者信息

Zhang X, Sun S, Hwang I, Tough D F, Sprent J

机构信息

Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

Immunity. 1998 May;8(5):591-9. doi: 10.1016/s1074-7613(00)80564-6.

DOI:10.1016/s1074-7613(00)80564-6

PMID:9620680

Abstract

Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits proliferation in vitro, IFN I-induced proliferation of CD8+ cells in vivo presumably occurs indirectly through production of secondary cytokines, e.g., interleukin-2 (IL-2) or IL-15. We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong and selective stimulation of memory-phenotype CD44hi CD8+ (but not CD4+) cells in vivo; similar specificity applies to purified T cells in vitro and correlates with much higher expression of IL-2Rbeta on CD8+ cells than on CD4+ cells.

摘要

感染因子诱导的记忆表型（CD44高表达）CD8⁺细胞增殖，可通过注射I型干扰素（IFN I）以及IFN I诱导剂（如脂多糖和聚肌胞苷酸）来模拟；这种增殖不影响初始T细胞，且似乎不依赖T细胞受体。由于IFN I在体外抑制增殖，因此IFN I在体内诱导的CD8⁺细胞增殖可能是通过次级细胞因子（如白细胞介素-2（IL-2）或IL-15）的产生间接发生的。我们在此表明，与IL-2不同，IL-15在体内引起对记忆表型CD44高表达CD8⁺（而非CD4⁺）细胞的强烈且选择性刺激方面，紧密模拟了IFN I的作用；类似的特异性在体外纯化的T细胞中也适用，并且与CD8⁺细胞上IL-2Rβ的表达远高于CD4⁺细胞相关。