通过拮抗细胞因子对CD8 +记忆性T细胞稳态的调控
Control of homeostasis of CD8+ memory T cells by opposing cytokines.
作者信息
Ku C C, Murakami M, Sakamoto A, Kappler J, Marrack P
机构信息
Howard Hughes Medical Institute, Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA.
出版信息
Science. 2000 Apr 28;288(5466):675-8. doi: 10.1126/science.288.5466.675.
Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.
记忆性T细胞在接触抗原后能长期维持其数量。我们在此表明，具有记忆表型的CD8⁺ T细胞在动物体内分裂缓慢。这种分裂需要白细胞介素-15，并且通过抑制白细胞介素-2（IL-2）可显著增加。因此，动物体内CD8⁺ 记忆性T细胞的数量受IL-15和IL-2之间平衡的控制。
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