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Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.

作者信息

Mitsuyasu H, Izuhara K, Mao X Q, Gao P S, Arinobu Y, Enomoto T, Kawai M, Sasaki S, Dake Y, Hamasaki N, Shirakawa T, Hopkin J M

出版信息

Nat Genet. 1998 Jun;19(2):119-20. doi: 10.1038/472.

DOI:10.1038/472
PMID:9620765
Abstract
摘要

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Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.白细胞介素4受体α亚基的Ile50Val变体上调免疫球蛋白E的合成并与特应性哮喘相关。
Nat Genet. 1998 Jun;19(2):119-20. doi: 10.1038/472.
2
Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.前沿：人类白细胞介素4受体α链Ile50Val变体在IgE合成中的主导作用。
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Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma.白细胞介素-4受体α链基因单倍型与特应性哮喘的易感性及严重程度相关。
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Role of CCL21 and CCL19 in allergic inflammation in the ovalbumin-specific murine asthmatic model.CCL21和CCL19在卵清蛋白特异性小鼠哮喘模型过敏性炎症中的作用
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The regulation of IgE synthesis.
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Regulation of the IgE allergic immune response by humoral and cellular factors.
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