受体活性修饰蛋白调节降钙素受体样受体的转运和配体特异性。

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

作者信息

McLatchie L M, Fraser N J, Main M J, Wise A, Brown J, Thompson N, Solari R, Lee M G, Foord S M

机构信息

Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK.

出版信息

Nature. 1998 May 28;393(6683):333-9. doi: 10.1038/30666.

DOI:10.1038/30666

PMID:9620797

Abstract

Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.

摘要

降钙素基因相关肽（CGRP）和肾上腺髓质素是具有不同药理学特性的相关肽。我们在此表明，一种具有七个跨膜结构域的受体，即降钙素受体样受体（CRLR），可作为CGRP受体或肾上腺髓质素受体发挥作用，这取决于我们称为受体活性修饰蛋白或RAMPs的新的单跨膜结构域蛋白家族的哪些成员被表达。RAMPs是将CRLR转运到质膜所必需的。RAMP1将受体呈现在细胞表面，作为一种成熟糖蛋白和CGRP受体。由RAMP2转运的受体是核心糖基化的，并且是肾上腺髓质素受体。