腺相关病毒通过缺失-替换机制定点整合到具有靶位点的附加体中。
Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanism.
作者信息
Dyall J, Berns K I
机构信息
Department of Microbiology, W. R. Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021, USA.
出版信息
J Virol. 1998 Jul;72(7):6195-8. doi: 10.1128/JVI.72.7.6195-6198.1998.
Abstract
Five site-specific adeno-associated virus integrants generated in a model system with an Epstein-Barr virus- based shuttle vector have been characterized. The results suggest a deletion-substitution mechanism of recombination.
摘要
在一个基于爱泼斯坦-巴尔病毒的穿梭载体模型系统中产生的五个位点特异性腺相关病毒整合体已得到鉴定。结果提示了一种重组的缺失-取代机制。
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Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanism.腺相关病毒通过缺失-替换机制定点整合到具有靶位点的附加体中。
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本文引用的文献
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J Virol. 1997 Dec;71(12):9231-47. doi: 10.1128/JVI.71.12.9231-9247.1997.
2
Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome.腺相关病毒Rep蛋白将DNA序列靶向人类基因组中的一个独特位点。
J Virol. 1997 Oct;71(10):7951-9. doi: 10.1128/JVI.71.10.7951-7959.1997.
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The roles of AAV Rep proteins in gene expression and targeted integration.腺相关病毒（AAV）Rep蛋白在基因表达和靶向整合中的作用。
Curr Top Microbiol Immunol. 1996;218:25-33. doi: 10.1007/978-3-642-80207-2_2.
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The recombination signals for adeno-associated virus site-specific integration.腺相关病毒位点特异性整合的重组信号。
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7966-72. doi: 10.1073/pnas.93.15.7966.
6
Site-specific integration by adeno-associated virus is directed by a cellular DNA sequence.腺相关病毒的位点特异性整合由细胞DNA序列指导。
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7
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