[中国胃癌组织中微卫星不稳定性的研究]

[Studies of microsatellite instability in Chinese gastric cancer tissues].

作者信息

Wang Y, Ke Y, Ning T, Feng L, Lu G, Liu W, E Z

机构信息

Department of Cancer Genetics, Beijing Institute for Cancer Research, Beijing Medical University, Beijing, 100034 P.R.China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Jun 10;15(3):155-7.

PMID:9621123

Abstract

OBJECTIVE

To identify the microsatellite instability(MSI) rates in Chinese gastric cancer samples.

METHODS

29 microsatellite markers were selected to examine 42 paired gastric cancer tissues for MSI on all chromosomes except Y.

RESULTS

The total frequency of MSI in all 42 gastric cancers was 33.9% with higher rates at loci of D3S1577, D3S1067,D8S279,D9S257, D1S248, D7S520 and D2S147,and the highest rate at D3S1577 and D3S1067(51.35%). MSI varied with different pathological types. The frequencies of MSI were signi- ficantly higher in poorly differentiated tumors and signet cell types, compared with well differentiated tumors(P=0.0026 and 0.0013 by chi-square test),and no difference was noted between poorly differentiated and signet cell types.

CONCLUSION

MSI may play an important role in Chinese gastric cancer, particularly the poorly differentiated adenocarcinomas. The data presented here further support the previous hypothesis that pathologically distinct subtypes of gastric cancer undergo different genetic pathways during tumorigenesis.

摘要

目的

确定中国胃癌样本中的微卫星不稳定性（MSI）发生率。

方法

选择29个微卫星标记，对42对胃癌组织进行检测，以分析除Y染色体外所有染色体上的MSI情况。

结果

42例胃癌中MSI的总发生率为33.9%，在D3S1577、D3S1067、D8S279、D9S257、D1S248、D7S520和D2S147位点发生率较高，其中D3S1577和D3S1067位点发生率最高（51.35%）。MSI随不同病理类型而变化。与高分化肿瘤相比，低分化肿瘤和印戒细胞型肿瘤中MSI的发生率显著更高（经卡方检验，P = 0.0026和0.0013），低分化肿瘤和印戒细胞型肿瘤之间未观察到差异。