Kruppa A, Scharffetter-Kochanek K, Krieg T, Hunzelmann N
Department of Dermatology, University of Cologne, Germany.
Dermatology. 1998;196(3):335-6. doi: 10.1159/000017907.
Allergic reactions to macrolides appear to be very rare. Only a few cases of fixed drug eruption or urticaria due to the administration of erythromycin have been reported. Cross-reaction between the different macrolides have not yet been published. We report a case of a 31-year-old female patient who developed generalized urticaria and tachycardia shortly after administration of roxithromycin (Rulid). Immediate-type hypersensitivity was confirmed by positive prick test reactions to roxithromycin and the chemically closely related macrolides erythromycin and clarithromycin.
对大环内酯类药物的过敏反应似乎非常罕见。仅报告了少数几例因使用红霉素而导致的固定性药疹或荨麻疹病例。不同大环内酯类药物之间的交叉反应尚未见报道。我们报告一例31岁女性患者，在服用罗红霉素（罗力得）后不久出现全身性荨麻疹和心动过速。通过对罗红霉素以及化学结构密切相关的大环内酯类药物红霉素和克拉霉素的阳性点刺试验反应，证实了速发型超敏反应。
