Khatun S S, Chowdhury S A, Begum S R, Rashid M, Khatun M S
Department of Obst. and Gynae, Institute of Postgraduate Medicine & Research, Dhaka.
Bangladesh Med Res Counc Bull. 1997 Dec;23(3):66-71.
The rate of Cesarean Section for failed induction of labor and maternal and fetal compilations are high when labor is induced in a nulliparas women with an unripe cervix by amniotomy and oxytocin infusion. Prostaglandins (PG) in different forms have been used for ripening the cervix with an aim of reducing these problems. A prospective randomized trial was performed on one hundred primigravid women between 37 and 42 weeks of gestation with singleton pregnancy, cephalic presentation and unfavorable cervix (Modified Bishop Score < or = 5) in the department of Obstetrics & Gynaecology of Institute of Postgraduate Medicine & Research from 1st May 1996 to 30th April 1997. In this study the efficiency of prostaglandin E2 intracervical (PGE2 IC) gel in induction of labor in a group of primigravid women with unripe cervix was assessed and compared with another group with similar characteristics using oxytocin infusion and artificial rupture of membrane (ARM). The Modified Bishop Score (MBS), interval between IOL and onset of labor and the duration of labor after insertion of PGE2 gel was significantly different from those of oxytocin infusion group. But the Apgar Score at 1 & 5 min had shown no statistically significant difference. Any significant difference could also not be detected in the mode of delivery between the two induction group. The proportion of emergency Cesarean Section (CS) was high in the oxytocin infusion group than that of in the prostaglandin group. There was also no significant difference regarding the acceptability of both the induction methods.
对于未成熟宫颈的初产妇，通过羊膜穿刺术和缩宫素静脉滴注引产时，引产失败率以及母婴并发症发生率较高。不同形式的前列腺素（PG）已被用于宫颈成熟，目的是减少这些问题。1996年5月1日至1997年4月30日，在研究生医学与研究所妇产科，对100例妊娠37至42周、单胎妊娠、头先露且宫颈条件不佳（改良Bishop评分≤5分）的初产妇进行了一项前瞻性随机试验。本研究评估了前列腺素E2宫颈内（PGE2 IC）凝胶对一组宫颈未成熟初产妇引产的有效性，并与另一组采用缩宫素静脉滴注和人工破膜（ARM）且特征相似的产妇进行比较。PGE2凝胶组的改良Bishop评分（MBS）、引产至临产的间隔时间以及PGE2凝胶置入后的产程与缩宫素静脉滴注组显著不同。但1分钟和5分钟时的阿氏评分无统计学显著差异。两组引产方式之间也未发现任何显著差异。缩宫素静脉滴注组急诊剖宫产（CS）的比例高于前列腺素组。两种引产方法的可接受性也无显著差异。
