Tabassum S, Rahman K M, Mamun K Z, Ahmed A N, Islam K M, Rahman H
Department of Microbiology, Institute of Postgraduate Medicine & Research, Dhaka.
Bangladesh Med Res Counc Bull. 1997 Dec;23(3):77-81.
Histopathology and direct immunofluorescence (DIF) microscopy were performed on renal biopsy specimens of 60 clinically suspected cases of glomerulonephritis (GN). Histopathological diagnosis was obtained in 44 (73.3%) cases and immune complex deposition were detected by DIF in 28 (46.7%) cases. Immune complex deposition were observed in all cases of membranous GN, systemic lupus erythematosus (SLE), and rapidly progressive GN (RPGN), most of the cases of diffuse proliferative GN (2 out of 3) mesangioproliferative GN (12 out of 15) and focal glomeruloscleros is (3 out of 5 cases). No immune deposits were observed in minimal change GN, chronic GN, and diabetic nephropathy. Histopathological diagnosis was not obtained in 16 (26.7%) cases, 3 (5%) of which showed immune complex deposition by DIF. Anti-GBM nephritis was demonstrated in one (3.6%) case, the rest were immune complex nephritis.
对60例临床疑似肾小球肾炎（GN）患者的肾活检标本进行了组织病理学和直接免疫荧光（DIF）显微镜检查。44例（73.3%）获得了组织病理学诊断，28例（46.7%）通过DIF检测到免疫复合物沉积。在所有膜性GN、系统性红斑狼疮（SLE）和快速进展性GN（RPGN）病例中均观察到免疫复合物沉积，大多数弥漫性增殖性GN病例（3例中的2例）、系膜增生性GN病例（15例中的12例）和局灶性节段性肾小球硬化病例（5例中的3例）也观察到免疫复合物沉积。在微小病变性GN、慢性GN和糖尿病肾病中未观察到免疫沉积物。16例（26.7%）未获得组织病理学诊断，其中3例（5%）通过DIF显示免疫复合物沉积。1例（3.6%）诊断为抗肾小球基底膜肾炎，其余为免疫复合物性肾炎。
