D'Auria L, Bonifati C, Mussi A, Ameglio F
Laboratorio Analisi Cliniche, IRCCS, Roma, Italia.
Clin Ter. 1998 Jan-Feb;149(921):49-52.
To determine the behaviour of serum levels of soluble E-selectin (sE-selectin), the soluble isoform of E-selectin, before/during/after therapy in patients with three.
Using commercially available ELISA kits, serum levels of sE-selectin have been determined in 15 patients with psoriasis, 15 with pemphigus vulgaris and 15 with bullous pemphigoid, and compared with those of 30 healthy subjects.
The results showed increased serum levels of sE-selectin in the three groups of patients as compared with those of 30 healthy subjects (p < 0.01). In addition, serum levels were significantly correlated with the disease activity expressed as Psoriasis Area and Severity Index (PASI score) (R = 0.56, p = 0.014) in psoriasis, and as number of the visible lesions (blisters/erosions), in the two bullous dermatoses (R = 0.81, p < 0.01). After therapy, the marker levels were significantly decreased (p < 0.01).
Overall, these data suggest that serum determinations of sE-selectin could represent a clinically useful indicator to monitor therapy.
确定三种疾病患者在治疗前/治疗期间/治疗后血清中可溶性E选择素(sE选择素)水平的变化情况。
使用市售酶联免疫吸附测定试剂盒,测定了15例银屑病患者、15例寻常型天疱疮患者和15例大疱性类天疱疮患者血清中sE选择素的水平,并与30名健康受试者的水平进行比较。
结果显示,与30名健康受试者相比,三组患者血清中sE选择素水平均升高(p<0.01)。此外,在银屑病中,血清水平与以银屑病面积和严重程度指数(PASI评分)表示的疾病活动度显著相关(R=0.56,p=0.014),在两种大疱性皮肤病中,血清水平与可见皮损数量(水疱/糜烂)显著相关(R=0.81,p<0.01)。治疗后,标志物水平显著降低(p<0.01)。
总体而言,这些数据表明,血清sE选择素测定可能是监测治疗的一项临床有用指标。