Kowalska A, Wender M, Lannfelt L
Institute of Human Genetics, Polish Academy of Sciences, Poznan.
Dement Geriatr Cogn Disord. 1998 May-Jun;9(3):137-9. doi: 10.1159/000017037.
The apolipoprotein E (APOE) gene has in many studies been identified as a susceptibility factor in Alzheimer's disease (AD). The APOE association is rather strong, but other not yet identified genetic factors are assumed to be involved in the pathogenesis of AD. Recently an association between an intronic polymorphism in presenilin-1 (PS-1) gene and late-onset AD was claimed. In order to confirm this observation we studied a sample of Polish patients with sporadic AD. However, our results did not confirm the existence of an association between the intronic polymorphism in the PS-1 gene and late-onset AD.
在许多研究中，载脂蛋白E（APOE）基因已被确定为阿尔茨海默病（AD）的一个易感因素。APOE的关联性相当强，但据推测，其他尚未确定的遗传因素也参与了AD的发病机制。最近有研究称早老素-1（PS-1）基因的一个内含子多态性与晚发型AD之间存在关联。为了证实这一观察结果，我们对一组波兰散发性AD患者进行了研究。然而，我们的结果并未证实PS-1基因内含子多态性与晚发型AD之间存在关联。
