DeGiorgio L A, Dibinis C, Milner T A, Saji M, Volpe B T
Department of Neurology and Neuroscience, Cornell University Medical School, The Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.
Brain Res. 1998 Jun 8;795(1-2):1-9. doi: 10.1016/s0006-8993(98)00247-9.
Neurotoxic injury of the caudate-putamen and lateral globus pallidus unilaterally initiated transneuronal degeneration of neurons in the ipsilateral substantia nigra reticulata (SNR). Quantification of SNR neurons using unbiased stereology demonstrated that neuron loss began 4 days after the initial striatal lesion, followed by significant loss (50%) at 6 days and a plateau at 8 days. Analysis at the light and ultrastructural levels revealed morphological changes consistent with a type of programmed cell death. These temporal and histological results refine an in vivo model in which to explore mechanisms of delayed neuronal degeneration.
