与人类乳头瘤病毒感染相关的低度宫颈上皮内瘤变。长期随访。
Low grade cervical intraepithelial neoplasia associated with human papillomavirus infection. Long-term follow-up.
作者信息
Matsuura Y, Kawagoe T, Toki N, Sugihara K, Kashimura M
机构信息
Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Kitakyushu, Japan.
出版信息
Acta Cytol. 1998 May-Jun;42(3):625-30. doi: 10.1159/000331818.
OBJECTIVE
To investigate the correlation between the development of low grade cervical intraepithelial neoplasia (LCIN) and human papillomavirus (HPV) infection in cases with long-term follow-up.
STUDY DESIGN
Forty-three cases of LCIN were followed for more than five years with cytology, colposcopy and Vira Pap. Coexistence of HPV infection was sought using a simplified HPV detection kit, the Vira Pap method (Dot Blot hybridization).
RESULTS
Regressive disease was noted in 21 cases, and persistent and progressive disease was noted in 22 cases. HPV DNA was negative in 81% (17 of 21) of regressive disease and positive in 55% (12 of 22) persistent and progressive disease. LCIN had disappeared in 17 (63%) of 27 cases negative for HPV DNA and was persistent or progressive in 12 (75%) of 16 cases positive for HPV DNA.
CONCLUSION
The clinical course of LCIN correlates well with HPV infection.
目的
通过长期随访，研究低度宫颈上皮内瘤变（LCIN）的发展与人类乳头瘤病毒（HPV）感染之间的相关性。
研究设计
43例LCIN患者接受了超过五年的细胞学、阴道镜检查及Vira Pap检测。采用简化的HPV检测试剂盒Vira Pap方法（斑点杂交法）检测HPV感染情况。
结果
21例出现病情消退，22例病情持续或进展。病情消退的病例中81%（21例中的17例）HPV DNA呈阴性，病情持续或进展的病例中55%（22例中的12例）HPV DNA呈阳性。HPV DNA阴性的27例中有17例（63%）LCIN消失，HPV DNA阳性的16例中有12例（75%）病情持续或进展。
结论
LCIN的临床病程与HPV感染密切相关。
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