Filous A, Burdová M
Dĕtská ocní klinika 2. LF UK a FN Motol, Praha.
Cesk Slov Oftalmol. 1998 Apr;54(2):86-90.
The authors evaluate the results of preoperative 5-minute administration of 5-fluorouracil (5-FU), 50 mg/ml, during trabeculectomy on 11 high risk eyes of children with primary and secondary glaucoma. The mean age of the patients was 7.3 years, the average follow-up period 8.9 months (6-12 months). The intraocular pressure (i.o.p) of 11 eyes before surgery varied between 23 and 46 torr, average 31.5 torr, after treatment it was 13 to 28 torr, average 18.4 torr. The mean drop of IOP was 41.6%. In 7 eyes during the last assessment of IOP < 21 torr with a drop of more than 30%. The remaining 4 eyes have a was IOP between 25 and 28 torr with a reduction of 19-39%. Serious postoperative complications comprised four times marked hypotonia with a shallow anterior chamber, twice choroidal ablation and once macular oedema associated with transient deterioration of vision. In view of the limited therapeutic possibilities of high risk types of glaucoma in children postoperative administration of 5-FU is a promising alternative for the reduction of IOP.
作者评估了在小梁切除术期间对11只患有原发性和继发性青光眼的高危儿童眼睛术前5分钟给予50毫克/毫升5-氟尿嘧啶（5-FU）的效果。患者的平均年龄为7.3岁，平均随访期为8.9个月（6 - 12个月）。11只眼睛术前的眼压在23至46托之间，平均为31.5托，治疗后为13至28托，平均为18.4托。眼压平均下降了41.6%。在最后一次眼压评估时，7只眼睛的眼压<21托，下降超过30%。其余4只眼睛的眼压在25至28托之间，降低了19 - 39%。严重的术后并发症包括4次明显的低眼压伴浅前房、2次脉络膜脱离和1次黄斑水肿伴视力短暂恶化。鉴于儿童高危型青光眼的治疗可能性有限，术后给予5-FU是降低眼压的一种有前景的替代方法。
