Terwindt G M, Ophoff R A, Haan J, Frants R R, Ferrari M D
Afd. Neurologie, Leids Universitair Medisch Centrum, Leiden.
Ned Tijdschr Geneeskd. 1998 May 2;142(18):1015-9.
There is increasing evidence of involvement of genes coding for ion channels in the pathogenesis of paroxysmal neurological disorders. Recently for instance, mutations in the calcium channel gene on chromosome 19 were identified in migraine, ataxia, and epilepsy. With the current research into inherited 'channelopathies' a new approach has been established. A better understanding of the pathophysiology of paroxysmal neurological disorders may lead to new therapeutic strategies.
越来越多的证据表明，编码离子通道的基因参与了阵发性神经系统疾病的发病机制。例如，最近在偏头痛、共济失调和癫痫中发现了19号染色体上钙通道基因的突变。随着目前对遗传性“通道病”的研究，一种新的方法已经建立起来。更好地理解阵发性神经系统疾病的病理生理学可能会带来新的治疗策略。
