Martinović Z, Perisić K, Pejnović N, Lukacević S, Rabrenović L, Petrović M
Military Medical Academy, Clinic for Gastroenterology, Belgrade.
Vojnosanit Pregl. 1998 Mar-Apr;55(2 Suppl):47-9.
Patients with inflammatory bowel diseases are susceptible to thrombosis in the active phase of the disease. Tests and some factors of coagulability have shown the existence of hypercoagulability of the blood in the active phase of these diseases. In the last few years some authors have found increased levels of antiphospholipid antibodies in the blood of patients with severe forms of Crohn's disease and ulcerative colitis. In a prospective study anticardiolipin antibodies have been measured in the blood of 12 patients, eight with ulcerative colitis and four with Crohn's disease. Six patients with ulcerative colitis and two with Crohn's disease were in the active phase of the disease, and the others in the remission. None of the patients had any clinical signs of thrombosis. Anticardiolipin antibodies were slightly increased in only one patient with severe ulcerative colitis complicated with erythema nodosum and swelling of the ankles. In nine patients anticardiolipin antibodies were in the normal range, but in two they were not found. Results of our study do not allow any definite conclusion regarding the possible role of antiphospholipid antibodies in the development of thrombosis in inflammatory bowel diseases: the number of the patients is relatively low and in half of the cases the disease was moderately active. Further studies are therefore necessary.
炎症性肠病患者在疾病活动期易发生血栓形成。凝血检测及一些凝血相关因素表明，这些疾病活动期存在血液高凝状态。在过去几年中，一些作者发现重症克罗恩病和溃疡性结肠炎患者血液中抗磷脂抗体水平升高。在一项前瞻性研究中，检测了12例患者血液中的抗心磷脂抗体，其中8例为溃疡性结肠炎患者，4例为克罗恩病患者。6例溃疡性结肠炎患者和2例克罗恩病患者处于疾病活动期，其余患者处于缓解期。所有患者均无血栓形成的临床体征。仅1例重症溃疡性结肠炎合并结节性红斑和踝关节肿胀的患者抗心磷脂抗体略有升高。9例患者抗心磷脂抗体在正常范围内，但2例未检测到。我们的研究结果无法就抗磷脂抗体在炎症性肠病血栓形成中的可能作用得出任何明确结论：患者数量相对较少，且半数病例疾病为中度活动期。因此，有必要进行进一步研究。
