D'Angelica M, Fong Y
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Surg Oncol Clin N Am. 1998 Jul;7(3):537-63.
Cytokine gene therapy is a potentially powerful antineoplastic strategy. It provides paracrine cytokine secretion in the region of putative tumor antigen that maximizes antitumor immune responses and minimizes systemic toxicity. A wealth of animal experimentation has demonstrated the effectiveness of cytokine gene therapy in a variety of tumor models. Enough evidence has mounted such that human cytokine gene therapy trials are underway throughout the United States and elsewhere.
细胞因子基因疗法是一种具有潜在强大作用的抗肿瘤策略。它能在假定肿瘤抗原区域实现旁分泌细胞因子分泌，从而使抗肿瘤免疫反应最大化，并将全身毒性降至最低。大量动物实验已证明细胞因子基因疗法在多种肿瘤模型中的有效性。已有足够证据积累，以至于美国及其他地区都在开展人类细胞因子基因疗法试验。
