Gasparoni A, De Amici D, Ciardelli L, Autelli M, Regazzi-Bonora M, Bartoli A, Chirico G, Rondini G
Research Laboratory (Paediatric Oncohaematology), Policlinico San Matteo-IRCCS, Pavia, Italy.
J Clin Immunol. 1998 May;18(3):210-3. doi: 10.1023/a:1020583022614.
Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) 15 infants born by cesarean section with epidural anesthesia, (B) 15 infants born by vaginal delivery, and (C) 20 infants born by cesarean section with general anesthesia. Chemotaxis levels were significantly lower in group A infants (35.5 +/- 16.1 microns) compared to groups B (54.6 +/- 10.5 microns) and C (71.4 +/- 23 microns). The highest cortisol levels were observed in vaginally delivered infants. A significant inverse relationship was observed between chemotaxis and lidocaine levels (r = -0.6, P = 0.016) in infants born by cesarean section after epidural anesthesia, while no significant correlation was observed between chemotaxis and cortisol level. In conclusion, lidocaine, transferred through the placenta to the fetus during epidural anesthesia, may have an inhibitory effect on chemotaxis.
麻醉药物可影响免疫系统，尤其是粒细胞功能。本研究的目的是评估剖宫产时用于硬膜外麻醉的利多卡因是否会影响新生儿中性粒细胞趋化性。我们测量了以下三组婴儿的趋化性以及脐血利多卡因和皮质醇水平：(A) 15例接受硬膜外麻醉剖宫产出生的婴儿，(B) 15例经阴道分娩出生的婴儿，以及(C) 20例接受全身麻醉剖宫产出生的婴儿。与B组（54.6±10.5微米）和C组（71.4±23微米）相比，A组婴儿的趋化性水平显著较低（35.5±16.1微米）。经阴道分娩的婴儿皮质醇水平最高。在硬膜外麻醉后剖宫产出生的婴儿中，趋化性与利多卡因水平之间存在显著负相关（r = -0.6，P = 0.016），而趋化性与皮质醇水平之间未观察到显著相关性。总之，硬膜外麻醉期间通过胎盘转移至胎儿的利多卡因可能对趋化性有抑制作用。
