Russell P, Nelson M, Whittington D, Green M, Eley S M, Titball R W
Br J Biomed Sci. 1997 Dec;54(4):231-6.
In response to an outbreak of a plague-like disease in India, the Public Health Laboratory Service (PHLS) in the UK distributed advice on the isolation and identification of Yersinia pestis. Some of the procedures outlined were evaluated using a number of isolates of Y. pestis, complemented with in-house techniques detecting virulence genes or their products. These laboratory investigations are limited in that they are either only indicative or they take too long (48 hours or more), and thus represent a serious delay to the patient. Successful patient management must be based on a case history, and therapy should be started immediately. Laboratory diagnosis will subsequently rule out most pathogens which cause similar infections, yet will still require confirmation by a reference laboratory.
针对印度爆发的一种类似鼠疫的疾病，英国公共卫生实验室服务局（PHLS）发布了关于鼠疫耶尔森菌隔离和鉴定的建议。所概述的一些程序使用了多种鼠疫耶尔森菌分离株进行评估，并辅以检测毒力基因或其产物的内部技术。这些实验室调查存在局限性，要么仅具有指示性，要么耗时过长（48小时或更长时间），因此对患者来说意味着严重延误。成功的患者管理必须基于病史，并且应立即开始治疗。实验室诊断随后将排除大多数引起类似感染的病原体，但仍需要参考实验室进行确认。
