Projan A, Nissen E
Arch Geschwulstforsch. 1976;46(1):50-7.
It is known that drugs are not unlimitedly stable. Dilutions of the antineoplastic agent daunoblastin used in the clinic and experimental work, were examined, whether they could be stored for several days. By means of impulscytophotometry, spectral-photometric measurements, counting of surviving cells and estimation of DNA-synthesis after culturing pieces of tissue in the presence of daunoblastin it could be established that this drug, diluted even four days ago, still possesses sufficient activity.
众所周知,药物并非具有无限稳定性。对临床及实验工作中使用的抗肿瘤药物柔红霉素的稀释液进行了检测,看其是否能保存数天。通过脉冲细胞光度测定法、分光光度测量、存活细胞计数以及在柔红霉素存在的情况下培养组织块后对DNA合成的评估,可以确定,即使是四天前稀释的这种药物仍具有足够的活性。