• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[柔红霉素溶液稳定性试验的研究(作者译)]

[Contribution to stability test of daunoblastin solutions (author's transl)].

作者信息

Projan A, Nissen E

出版信息

Arch Geschwulstforsch. 1976;46(1):50-7.

PMID:962502
Abstract

It is known that drugs are not unlimitedly stable. Dilutions of the antineoplastic agent daunoblastin used in the clinic and experimental work, were examined, whether they could be stored for several days. By means of impulscytophotometry, spectral-photometric measurements, counting of surviving cells and estimation of DNA-synthesis after culturing pieces of tissue in the presence of daunoblastin it could be established that this drug, diluted even four days ago, still possesses sufficient activity.

摘要

众所周知,药物并非具有无限稳定性。对临床及实验工作中使用的抗肿瘤药物柔红霉素的稀释液进行了检测,看其是否能保存数天。通过脉冲细胞光度测定法、分光光度测量、存活细胞计数以及在柔红霉素存在的情况下培养组织块后对DNA合成的评估,可以确定,即使是四天前稀释的这种药物仍具有足够的活性。

相似文献

1
[Contribution to stability test of daunoblastin solutions (author's transl)].[柔红霉素溶液稳定性试验的研究(作者译)]
Arch Geschwulstforsch. 1976;46(1):50-7.
2
Enhancement by cyclosporin A of daunorubicin efficacy in Ehrlich ascites carcinoma and murine hepatoma 129.环孢素A增强柔红霉素对艾氏腹水癌和小鼠肝癌129的疗效。
Cancer Res. 1987 Dec 1;47(23):6216-9.
3
Inhibition of DNA and RNA synthesis by daunorubicin in sensitive and resistant Ehrlich ascites tumor cells in vitro.柔红霉素在体外对敏感和耐药艾氏腹水瘤细胞DNA和RNA合成的抑制作用。
Cancer Res. 1972 Jun;32(6):1307-14.
4
[Cytophotometric measurements of desoxyribonucleic acids and total protein content in Ehrlich tumour cells treated by daunomycin or amphotericin B (author's transl)].[道诺霉素或两性霉素B处理的艾氏腹水癌细胞中脱氧核糖核酸和总蛋白含量的细胞光度测定(作者译)]
Ann Histochim. 1975 Apr-Jun;20(2):101-7.
5
Daunomycin pharmacological activity at the cellular level.柔红霉素在细胞水平的药理活性。
Pathol Biol. 1967 Oct;15(19):897-902.
6
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.阿柔比星对柔红霉素诱导的人小细胞肺癌细胞毒性的拮抗作用:与DNA完整性和拓扑异构酶II的关系
Cancer Res. 1991 Oct 1;51(19):5093-9.
7
[Comparative study of the toxicity and antitumor activity of a DNA-rubomycin complex and free rubomycin].[柔红霉素-DNA复合物与游离柔红霉素的毒性及抗肿瘤活性的比较研究]
Antibiotiki. 1981 May;26(5):361-5.
8
[Effect of nitidine chloride on the life cycle of Ehrlich ascites carcinoma cells in mice (author's transl)].氯化两面针碱对小鼠艾氏腹水癌细胞生命周期的影响(作者译)
Zhongguo Yao Li Xue Bao. 1981 Mar;2(1):46-9.
9
DNA breaks in P288 tumor cells in mice after treatment with daunorubicin and adriamycin.用柔红霉素和阿霉素处理后小鼠P288肿瘤细胞中的DNA断裂。
Res Commun Chem Pathol Pharmacol. 1975 Jan;10(1):51-64.
10
Circumvention of resistance to daunorubicin by N-acetyldaunorubicin in Ehrlich ascites tumor.N-乙酰柔红霉素对艾氏腹水瘤中柔红霉素耐药性的规避作用
Cancer Res. 1980 Apr;40(4):1077-83.

引用本文的文献

1
Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.蒽环类抗肿瘤药物。物理化学、分析及稳定性性质综述。
Pharm Weekbl Sci. 1986 Apr 25;8(2):109-33. doi: 10.1007/BF02086146.