Marzotko F, Krafft W, Preibsch W, Schröder M
Arch Geschwulstforsch. 1976;46(2):140-5.
201 pretherapeutic tests for sensitivity of gynaecologic cancers against 5-fluorouracil were performed. Only 8.5% of cases proved to be sensitive in tissue culture. Clinical results with 5-FU monotherapy were unsatisfactory. 5-FU should only be used very critically in gynaecologic neoplasims. The value of predictive tests for sensitivity against cytostatics in planning individualized selective chemotherapy is emphasized.
进行了201项妇科癌症对5-氟尿嘧啶的治疗前敏感性测试。在组织培养中,仅8.5%的病例被证明敏感。5-氟尿嘧啶单药治疗的临床结果并不理想。在妇科肿瘤中,5-氟尿嘧啶的使用应非常谨慎。强调了在规划个体化选择性化疗时,针对细胞毒性药物敏感性的预测测试的价值。