Reisser D, Lagadec P, Arnould L, Onier N, Maupoil V, Pinard D, Jeannin J F
Ecole Pratique des Hautes Etudes, Cancer Immunotherapy Research Laboratory, Faculty of Medicine, Dijon, France.
Cancer Immunol Immunother. 1998 May;46(3):160-6. doi: 10.1007/s002620050474.
Nitric oxide (NO) has been shown to inhibit the proliferation of lymphocytes. However, in tumour-bearing rats treated with the immunomodulator OM 163, the regressing nodules were heavily infiltrated by T lymphocytes, although they contained high levels of NO. We show here that NO, while inhibiting the proliferation of lymphocytes, increased their life-span, pointing to the ambivalence of this molecule in the course of tumour growth and regression.
一氧化氮（NO）已被证明可抑制淋巴细胞的增殖。然而，在用免疫调节剂OM 163治疗的荷瘤大鼠中，尽管消退结节中含有高水平的NO，但仍有大量T淋巴细胞浸润。我们在此表明，NO虽然抑制淋巴细胞的增殖，但却延长了它们的寿命，这表明该分子在肿瘤生长和消退过程中具有矛盾性。
