Saitoh T, Murakami H, Hayashi K, Matsushima T, Tamura J, Karasawa M, Naruse T, Tsuchiya J
Division of Blood Transfusion Service, Gunma University School of Medicine, Maebashi, Japan.
Am J Hematol. 1998 Jun;58(2):127-9. doi: 10.1002/(sici)1096-8652(199806)58:2<127::aid-ajh7>3.0.co;2-u.
We experienced two rare cases of pernicious anemia that presented in the course of mycosis fungoides in elderly males. Pernicious anemia has recently been reported to be caused by autoimmune gastritis that produces autoantibodies to gastric parietal cells and intrinsic factor. Immunological abnormalities in mycosis fungoides are reported to induce autoimmune diseases (i.e., autoimmune hemolytic anemia, anti-phospholipid antibody syndrome, arthritis, myasthenia gravis, necrotizing vasculitis, and vitiligo); the pernicious anemia in our two patients may have been closely related to the mycosis fungoides.
我们遇到了两例罕见的恶性贫血病例，均出现在老年男性蕈样肉芽肿病程中。最近有报道称，恶性贫血是由自身免疫性胃炎引起的，这种胃炎会产生针对胃壁细胞和内因子的自身抗体。据报道，蕈样肉芽肿中的免疫异常会诱发自身免疫性疾病（即自身免疫性溶血性贫血、抗磷脂抗体综合征、关节炎、重症肌无力、坏死性血管炎和白癜风）；我们这两名患者的恶性贫血可能与蕈样肉芽肿密切相关。
