Wu C W, Li A F, Chi C W, Chung W W, Liu T Y, Lui W Y, P'eng F K
Department of Surgery, Veterans General Hospital-Taipei, Taipei, 11217 Taiwan, R.O.C.
Oncol Rep. 1998 Jul-Aug;5(4):817-22. doi: 10.3892/or.5.4.817.
Overexpression and amplification of Met/HGF receptor has been detected in gastric cancer tissues and cell lines. In this study hepatocyte growth factor (HGF) and Met/HGF receptors were localized in 32 gastric cancer and adjacent normal gastric tissues by the avidin-biotin-peroxidase complex technique. HGF (87.5%) and Met/HGF receptors (68.8%) were demonstrated in gastric cancer tissues. A high positive rate of HGF (87.0%) and Met/ HGF receptors (82.6%) presented in intestinal type gastric cancer. HGF immunoreactivity in gastric cancer tissues was a significant and powerful prognostic indicator (relative risk 15.9; p=0.01). These data suggest that HGF and Met/HGF receptors are involved in the morphogenesis of intestinal type gastric cancer. HGF may have other mechanism that favor gastric cancer spread and independently affect survival.
在胃癌组织和细胞系中已检测到Met/HGF受体的过表达和扩增。在本研究中，采用抗生物素蛋白-生物素-过氧化物酶复合物技术，对32例胃癌组织及癌旁正常胃组织中的肝细胞生长因子（HGF）和Met/HGF受体进行了定位。胃癌组织中显示有HGF（87.5%）和Met/HGF受体（68.8%）。肠型胃癌中HGF（87.0%）和Met/HGF受体（82.6%）呈现高阳性率。胃癌组织中的HGF免疫反应性是一个显著且有力的预后指标（相对风险15.9；p=0.01）。这些数据表明，HGF和Met/HGF受体参与了肠型胃癌的形态发生。HGF可能还有其他促进胃癌扩散并独立影响生存的机制。
