Kikuyama S, Kubota T, Shimizu K, Miyakita M
Department of Surgery, Saiseikai Central Hospital, Minato-ku, Tokyo 108-0073, Japan.
Oncol Rep. 1998 Jul-Aug;5(4):867-70. doi: 10.3892/or.5.4.867.
One hundred and thirty surgical specimens of gastric adenocarcinoma were obtained from patients who had undergone radical gastrectomy. The samples were formalin-fixed, paraffin-embedded and used for immunostaining of Ki-67 antigen. Mean Ki-67 index was 41.8% (SD 15. 7%, range 8.2-84.2%). Differentiated carcinomas had a higher Ki-67 index than undifferentiated tumors, although other clinicopathological variables, including lymph node metastasis and depth of invasion showed no correlation with Ki-67 index. In the undifferentiated tumors, Ki-67 index correlated with lymph node involvement. A high Ki-67 index ( 55%) was found to be an independent indicator of poor prognosis in patients with undifferentiated tumors.
从接受根治性胃切除术的患者中获取了130份胃腺癌手术标本。样本经福尔马林固定、石蜡包埋后用于Ki-67抗原的免疫染色。Ki-67指数的平均值为41.8%（标准差15.7%，范围8.2 - 84.2%）。尽管包括淋巴结转移和浸润深度在内的其他临床病理变量与Ki-67指数无相关性，但分化型癌的Ki-67指数高于未分化肿瘤。在未分化肿瘤中，Ki-67指数与淋巴结受累情况相关。发现高Ki-67指数（＞55%）是未分化肿瘤患者预后不良的独立指标。
