Nain M, Kohlhage H
Arch Virol. 1976;51(1-2):151-5. doi: 10.1007/BF01317844.
Splenectomy in rabbits causes a temporary reduction in interferon responding capacity of Poly I:C, followed by a period of hyperreactivity. At the same time a fraction of interferon with slightly different physiocochemical properties emerges. This could indicate that the spleen plays a relatively important role in the interferon response to Poly I:C. Splenectomy could be followed by the development of a compensatory cell population responsible for the production of interferon with slightly different molecular weight, isoelectric point and stability in urea.
兔脾脏切除会导致对聚肌胞（Poly I:C）的干扰素反应能力暂时降低，随后会出现一段反应过度期。与此同时，会出现一部分理化性质略有不同的干扰素。这可能表明脾脏在对聚肌胞的干扰素反应中发挥相对重要的作用。脾脏切除后可能会形成一个代偿性细胞群体，负责产生分子量、等电点及在尿素中的稳定性略有不同的干扰素。
