Knecht S, Deppe M, Ringelstein E B, Wirtz M, Lohmann H, Dräger B, Huber T, Henningsen H
Department of Neurology, University of Münster, Germany.
Stroke. 1998 Jun;29(6):1155-9. doi: 10.1161/01.str.29.6.1155.
Since functional transcranial Doppler ultrasonography (fTCD) allows convenient and fully automated quantification of language lateralization, it seems ideal for longitudinal studies of perfusion changes during deterioration as well as recovery of language functions. However, during serial examinations, the technical, stochastic, and physiological variabilities of cerebral blood flow velocities (CBFV) have to be considered. Therefore, before fTCD is accepted as a tool for evaluation of changes in lateralization in the diseased state, its reliability in healthy subjects needs to be determined.
We performed fTCD during a word generation task based on a previously validated technique with automated calculation of the averaged CBFV differences in the middle cerebral arteries providing an index of lateralization (LI).
(1) The accuracy of the LI as assessed by the confidence interval was better than 1% of the mean hemispheric difference. (2) On repeated examination, LIs obtained from 10 subjects showed a high test-retest reproducibility (Pearson product moment correlation coefficient r = 0.95, P < 0.0001). (3) On 10 repeated assessments of LI in the same subject, no practice effects were detected.
Functional TCD is a suitable and very robust tool for the longitudinal quantitative measurement of cerebral language lateralization.
由于功能性经颅多普勒超声检查（fTCD）能够方便且完全自动化地对语言侧化进行量化，它似乎是研究语言功能恶化及恢复过程中灌注变化的纵向研究的理想工具。然而，在系列检查过程中，必须考虑脑血流速度（CBFV）的技术、随机和生理变异性。因此，在fTCD被接受作为评估疾病状态下侧化变化的工具之前，需要确定其在健康受试者中的可靠性。
我们基于先前验证的技术，在单词生成任务期间进行fTCD，自动计算大脑中动脉平均CBFV差异，以提供侧化指数（LI）。
（1）通过置信区间评估的LI准确性优于平均半球差异的1%。（2）在重复检查中，从10名受试者获得的LI显示出高重测再现性（皮尔逊积矩相关系数r = 0.95，P < 0.0001）。（3）在同一受试者对LI进行10次重复评估时，未检测到练习效应。
功能性TCD是用于大脑语言侧化纵向定量测量的合适且非常可靠的工具。
